Acute leukemia viruses E26 and avian myeloblastosis virus have related transformation-specific RNA sequences but different genetic structures, gene products, and oncogenic properties

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Acute leukemia viruses E26 and avian myeloblastosis

Replication-defective acute leukemia viruses E26 and myeloblastosis virus (AMV) cause distinct leukemias although they belong to the same subgroup of oncogenic avian tumor viruses based on shared transformation-specific (onc) RNA sequences. E26 causes predominantly erythroblastosis in chicken and in quail, whereas AMV induces a myeloid leukemia. However, upon cultivation in vitro for >1 month, ...

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The oncogenic effects of nontransforming viruses from avian myeloblastosis virus.

Standard avian myeloblastosis virus (AMV), BAI strain A, causes myeloblastosis, osteopetrosis, lymphoid leukosis, and nephroblastoma in chickens. In this investigation, several leu kosis viruses of subgroups A and B were isolated (rom standard AMV and characterized. A subgroup A virus derived from an AMV-induced lymphoma of a Japanese quail was isolated, and it induced a high incidence of osteo...

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Avian myeloblastosis virus and E26 virus oncogene products are nuclear proteins.

The defective acute leukemia viruses avian myeloblastosis virus (AMV) and E26 virus each contain an inserted cellular sequence related to the same highly conserved cellular gene, proto-amv. The oncogenes of these two retroviruses differ from this cellular proto-oncogene in gene structure, transcript structure, and gene product. The product of the AMV oncogene (myb) is a 48,000 Mr protein, p48my...

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Genetic structure of avian myeloblastosis virus, released from transformed myeloblasts as a defective virus particle.

Chicken myeloblasts transformed by avian myeloblastosis virus (AMV) in the absence of nondefective helper virus (termed nonproducer cells) were found to release a defective virus particle (DVP) that contains avian tumor viral gag proteins but lacks envelope glycoprotein and a DNA polymerase. Nonproducer cells contain a Pr76 gag precursor protein and also a protein that is indistinguishable from...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1982

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.79.12.3677